Terns Pharmaceuticals Announces First Participant Dosed in Phase 1 Clinical Trial of TERN-601 Oral GLP-1 Receptor Agonist for Treatment of Obesity
Phase 1 trial underway for Terns’ first oral GLP-1R agonist candidate for obesity, with 28-day proof of concept data anticipated in 2H24
Oral GLP-1R agonist offers potential for weight loss and improved convenience compared to currently marketed injectables
Excerpt from the Press Release:
FOSTER CITY, Calif., Nov. 02, 2023 (GLOBE NEWSWIRE) — Terns Pharmaceuticals, Inc. (“Terns” or the “Company”) (Nasdaq: TERN), a clinical-stage biopharmaceutical company developing a portfolio of small-molecule product candidates to address serious diseases, including oncology, obesity and non-alcoholic steatohepatitis (NASH), today announced that the first participant has been dosed in the Phase 1 clinical trial of TERN-601, the Company’s oral small-molecule glucagon-like peptide-1 receptor, or GLP-1R, agonist for the treatment of obesity.
“We are excited to initiate this first-in-human study of our oral GLP-1R agonist, TERN-601, as we believe it represents a potentially meaningful alternative to the currently marketed injectable GLP-1R agonist treatments,” said Erin Quirk, MD, president and head of research and development at Terns. “TERN-601 represents our first internally discovered small molecule GLP-1R agonist, which is designed to be administered orally once daily with a competitive profile for weight loss, both as a monotherapy and as part of a potential all oral combination treatment for obesity.”
“We are encouraged by the prospects for our obesity franchise and look forward to reporting initial 28-day weight loss proof of concept data from the Phase 1 trial of TERN-601, which is anticipated in the second half of 2024. We also have ongoing discovery efforts in obesity with our TERN-600 series of additional small molecule GLP-1R agonists and our TERN-800 series of small-molecule glucose-dependent insulinotropic polypeptide receptor (GIPR) modulators, which have the potential to be combined with GLP-1R agonists. These programs along with TERN-501, our highly selective THR-β agonist in development for the treatment of NASH, aim to meaningfully improve clinical outcomes for patients battling metabolic diseases, with better potential tolerability, accessibility and ease-of-use than currently available treatments,” added Dr. Quirk.
Click the button below to read the entire Press Release:
Discover What Sets TrialStat Apart From Ordinary EDC Platforms
Click the image or button below to explore our eClinical Suite Platform and discover what sets TrialStat apart from competing EDC platforms.
Request Your Demo Today!
From rapid database build through database lock, we deliver consistent quality on-time and on-budget. Ready to upgrade your eClinical toolkit?