Turnstone Biologics Presents Preclinical Data Highlighting Potential for Selected Tumor-Infiltrating Lymphocyte (TIL) Therapy in Solid Tumors at the 2023 Society for Immunotherapy of Cancer (SITC) Annual Meeting

Presentations showcase Turnstone’s novel Selected TIL programs which are designed to selectively expand the most potent tumor-reactive T cells for treatment of solid tumors

Data further supports the continued clinical advancement of TIDAL-01, Turnstone’s lead Selected TIL therapy, currently being evaluated in two Phase 1 trials

Results also demonstrate the potential for a streamlined and rapid selection process and genetic engineering of Selected TIL to further enhance function

Excerpt from the Press Release:

SAN DIEGO, Nov. 03, 2023 (GLOBE NEWSWIRE) — Turnstone Biologics Corp. (“Turnstone” or the “Company”) (Nasdaq: TSBX), a clinical-stage biotechnology company developing a differentiated approach to treat and cure patients with solid tumors by pioneering selected tumor-infiltrating lymphocyte (Selected TIL) therapy, today announced it will be presenting four posters highlighting preclinical data from its pipeline of programs, including the lead clinical candidate, TIDAL-01, at the Society for Immunotherapy of Cancer (SITC) 38^th Annual Meeting being held November 1-5, 2023 in San Diego, California.

“Perhaps the greatest challenge that restricts the clinical application of current TIL therapies across a broad range of solid tumors is the low number of T cells that can recognize and attack these tumors,” said Stewart Abbot, Ph.D., Turnstone’s Chief Scientific Officer. “We are solving for this problem by specifically selecting and expanding the most potent tumor-reactive T cells, which we believe are crucial to the successful development of TIL-based therapies. We are pleased to share the promising results presented at SITC that further highlight our differentiated approach. Building on previous evidence, these data continue to demonstrate the potential for TIDAL-01 and our other pipeline programs to achieve objective responses in solid tumors, where limited treatment options are available.”

Key findings from the four poster presentations follow, copies of which will be added to Turnstone’s website and can be accessed here.

Title: Expansion and Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes (TIL) from Metastatic Colorectal (CRC) and GI Cancers
Date and Time: Saturday, November 4, 2023, 9:00am – 8:30pm PT
Abstract Number: 346
In collaboration with H. Lee Moffitt Cancer Center (Moffitt)

• Turnstone’s lead Selected TIL clinical candidate, TIDAL-01, utilizes a novel unbiased identification and functional screening process to isolate and selectively expand the greatest breadth of the most potent tumor-reactive (neoantigen-reactive) TIL from the patient’s tumor in vitro, before infusing them into the patient for more targeted tumor killing.

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