Maze Therapeutics Announces Initiation of Dosing in Phase 1 Trial Evaluating MZE829, a Novel Oral APOL1 Inhibitor, as a Potential Treatment for APOL1 Kidney Disease

Maze Therapeutics Announces Initiation of Dosing in Phase 1 Trial Evaluating MZE829, a Novel Oral APOL1 Inhibitor, as a Potential Treatment for APOL1 Kidney Disease

Excerpt from the Press Release:

SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–Maze Therapeutics, a company translating genetic insights into new precision medicines, today announced the initiation of dosing in the company’s Phase 1 trial of MZE829 in healthy volunteers. MZE829 is an oral, small molecule apolipoprotein L1 (APOL1) inhibitor designed to block APOL1 pore function and ameliorate manifestations of APOL1 kidney disease.

“The start of this trial marks the second program identified through our Compass™ platform to enter clinical development—a testament to Maze’s ability to leverage the wealth of genetic and clinical data we have aggregated and analyzed to create better medicines for patients”

“The start of this trial marks the second program identified through our Compass™ platform to enter clinical development—a testament to Maze’s ability to leverage the wealth of genetic and clinical data we have aggregated and analyzed to create better medicines for patients,” said Harold Bernstein, M.D., Ph.D., president, research and development, and chief medical officer of Maze. “This is also an important stepping stone in our strategy of bringing potentially disease-modifying treatments to people with common diseases – like kidney disease – using our genetically informed approach to drug discovery. Ultimately, we hope that this study will provide important first-in-human insights that allow us to expand evaluation of MZE829 in a broader chronic kidney disease population who have APOL1 kidney disease.”

APOL1 is a protein encoded by the APOL1 gene in humans. Genetic variants of the gene (G1 and G2) are associated with increased risk for a spectrum of progressive kidney diseases in the Black community. MZE829 was identified through insights generated with Maze’s proprietary, purpose-built platform, Maze Compass™. In preclinical studies, administration of Maze’s APOL1 inhibitor has been well tolerated and has led to amelioration of albuminuria in both chronic and acute humanized models of APOL1 kidney disease, with demonstrated improvement in the associated tissue pathology.

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