Aspen Neuroscience Announces First Patient Dosed in First-in-Human Phase 1/2a Clinical Trial of Autologous Neuronal Cell Replacement Therapy for Parkinson’s Disease
Excerpt from the Press Release:
First U.S. Multi-center, Multi-patient Phase 1/2a Trial of an Autologous Neurological Therapy
SAN DIEGO, April 17, 2024 /PRNewswire/ — Aspen Neuroscience, Inc. announced that the first patient has been dosed in the ASPIRO trial, a Phase 1/2a open label clinical trial to assess safety and tolerability of ANPD001, an autologous, dopaminergic neuron cell replacement therapy for participants with moderate to severe Parkinson’s disease (PD). Aspen Neuroscience is a private biotechnology company developing personalized regenerative therapies.
The first transplantation procedure in the ASPIRO study was performed by Banner – University Medical Center Tucson neurosurgeon Paul Larson, MD, FAANS, professor of neurosurgery at the University of Arizona College of Medicine – Tucson. The hospital is one of five clinical sites for the Phase 1/2a trial. Dr. Larson is the lead neurosurgeon and Banner – University Medicine Tucson is the lead dosing site for the ASPIRO study.
Dr. Larson is a pioneer in the field of interventional MRI-guided stereotaxy, and has performed over 1,000 iMRI procedures. His clinical research team has been the solo or lead group in 12 cell and gene therapy clinical research trials since 2004, and is one of the top teams in intracranial delivery of novel therapeutics for neurodegenerative disorders.
“Parkinson’s disease is the most common neurodegenerative movement disorder, primarily affecting the depletion of dopamine neurons in the midbrain. By the time of diagnosis, it is common for people with Parkinson’s to have lost the majority of dopaminergic (DA) neurons in the nigrostriatal pathway, which leads to progressive loss of motor and neurological function,” explained Dr. Larson. “This is the first use of the autologous approach in a formal clinical trial, and it is an honor to be part of this important study.”
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