D2M Biotherapeutics Announces First Patient Dosed in A Phase 1 Study Evaluating DM919, a Novel MICA/B Antibody for Treating Patients with Advanced Solid Tumors
Excerpt from the Press Release:
In the news release, D2M Biotherapeutics Announces First Patient Dosed in A Phase 1 Study … issued 18-Apr-2024 by D2M Biotherapeutics, Inc. over PR Newswire, the headline was incorrectly separated by PR Newswire into two parts. The corrected release (with headline intact) follows:
D2M Biotherapeutics Announces First Patient Dosed in A Phase 1 Study Evaluating DM919, a Novel MICA/B Antibody for Treating Patients with Advanced Solid Tumors
NATICK, Mass., April 18, 2024 /PRNewswire/ — D2M Biotherapeutics, Inc. (D2M), a clinical stage biotech company focused on developing innovative therapies in treating Immunological-Inflammatory diseases and cancers, today announced that the first patient had been dosed in a phase 1, open-label, dose escalation and expansion study of DM919, a novel monoclonal antibody targeting MICA/B to restore and promote anti-tumor response by T and natural killer (NK) cells for the treatment of advanced solid tumors.
This phase 1, first-in-human, multicenter, dose-escalation and expansion trial (NCT06328673) will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical activity of DM919 alone and in combination with anti-PD1 therapy in patients with advanced or metastatic solid tumors.
“The initiation of this clinical study represents a major milestone for D2M,” said Nan Bing, MD., Ph.D., co-founder and CEO of D2M. “The MICA/B targeted therapy is a novel modality in cancer treatment through its unique mode-of-action by addressing MICA/B mediated immune escape presented in many types of tumors. It also has potential to bring effective treatment against certain tumors with MHC-I low expression, which are typically resistant to the current immune check inhibitor agents. We are thrilled to work with our Principal Investigator, Dr. Shiraj Sen at Next Oncology to assess DM919’s safety and clinical activities in this Ph1 study.”
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