Mythic Therapeutics Announces Publication of Preclinical Data Highlighting the Differentiating Properties of MYTX-011 in Molecular Cancer Therapeutics
Excerpt from the Press Release:
WALTHAM, Mass.–(BUSINESS WIRE)–Mythic Therapeutics, a clinical-stage biotechnology company committed to the development of next-generation antibody-drug conjugate (ADC) therapies for the treatment of a wide range of cancers, today announced the publication of preclinical data highlighting the differentiating properties of its investigational cMET-targeting ADC, MYTX-011, in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research (AACR).
“The potential of novel ADC technologies to enhance payload delivery to tumors is relatively underexplored compared to advances in linker-payload technology and target selection,” said Nimish Gera, Ph.D., lead author of the paper and Scientific Co-founder, Vice President of Biologics at Mythic. “We believe that engineering pH-dependent binding could be a particularly compelling strategy for ADCs targeting medium to low levels of cMET expression in patients. We’re pleased to publish this study illustrating how the properties of MYTX-011, including its potential for increased on-target potency, enhanced tolerability, longer half-life and higher efficacy, may enable this therapy to serve patients with a broad range of cMET expression who otherwise have limited treatment options. We look forward to continuing to evaluate MYTX-011 in our ongoing Phase 1 clinical trial.”
The study demonstrated that incorporation of pH-dependent binding in the antibody component of a cMET targeting ADC can overcome the requirement for high cMET expression on tumors, an innovation that has the potential to benefit a broader population of patients with lower cMET levels. MYTX-011 drove four-fold higher net internalization than a non-pH engineered parent ADC in non-small cell lung cancer (NSCLC) cells and showed increased cytotoxicity against a panel of cell lines from various solid tumors, including head and neck, gastric, pancreatic, esophageal, bladder, kidney and skin cancer.
Click the button below to read the entire Press Release:
Discover What Sets TrialStat Apart From Ordinary EDC Platforms
Click the image or button below to explore our eClinical Suite Platform and discover what sets TrialStat apart from competing EDC platforms.
Request Your Demo Today!
From rapid database build through database lock, we deliver consistent quality on-time and on-budget. Ready to upgrade your eClinical toolkit?