eClinical Technology and Industy News

Nutcracker Therapeutics’ Research Partner, the University of California, San Francisco, Presents Foundational Prostate Cancer Data at AAI 2024

  • Study used Nutcracker Therapeutics’ mRNA nanoparticles to map prostate cancer antigen reactivity across patient cohorts and clinical outcomes
  • Longstanding research partnership between UCSF and Nutcracker Therapeutics underscores commitment to novel prostate cancer therapeutic development, including mRNA drug candidate NTX-470

Excerpt from the Press Release:

EMERYVILLE, Calif.–(BUSINESS WIRE)–Nutcracker Therapeutics, Inc., a biotechnology company dedicated to developing transformative RNA therapies through its proprietary technology platform, today detailed data presented by its partners at the University of California, San Francisco (UCSF) on foundational prostate cancer antigen research utilized to inform the development of its mRNA drug candidate, NTX-470. The data were presented by lead author Elena Montauti, Ph.D., from UCSF on May 4, during the 2024 Annual Meeting of the American Association of Immunologists (AAI) in Chicago.

It is well established that prostate cancer is a “cold cancer” with low immunogenicity. Its low mutation burden has resulted in very few druggable neoantigens – leaving shared tumor-associated antigens (TAAs) as the primary targets for immunotherapeutic development. However, the larger landscape of which shared prostate TAAs are immunogenic targets is challenging to assess and has not been systemically studied across patients. Further, it is unknown how antigen immunogenicity evolves as the disease progresses. The research presented at AAI aimed to map antigen reactivity in prostate cancer to inform possible combinations of TAAs that could be used as treatment for the disease.

Using its Nutshell® technologies, Nutcracker Therapeutics’ scientists worked with UCSF researchers to create mRNAs encoding eight common and shared prostate TAAs, and employed a novel antigen recall assay to systematically study T cell immune responses in blood samples of patients with localized and metastatic prostate cancer.

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