Foghorn Therapeutics Announces First Patient Dosed with First-in-Class Oral SMARCA2 Selective Inhibitor FHD-909 in a Phase 1 Trial for SMARCA4 Mutated Solid Tumors

Primary target patient population for the FHD-909 Phase 1 trial is non-small cell lung cancer (NSCLC)

Lilly leads the clinical development of the Phase 1 trial

Foghorn’s selective SMARCA2 oncology program is part of a U.S. 50/50 co-development and co-commercialization collaboration with Lilly

Excerpt from the Press Release:

CAMBRIDGE, Mass., Oct. 10, 2024 (GLOBE NEWSWIRE) — October 10, 2024 — Foghorn® Therapeutics Inc. (Nasdaq: FHTX), a clinical-stage biotechnology company pioneering a new class of medicines that treat serious diseases by correcting abnormal gene expression, today announced that the first patient has been dosed with FHD-909 (LY4050784) in the Phase 1 trial for SMARCA4 (BRG1) mutated cancers, with non-small cell lung cancer (NSCLC) as the primary target patient population. FHD-909 is a first-in-class oral, highly potent compound that demonstrates high selectivity for SMARCA2 (BRM) over SMARCA4, a closely related protein.

“FHD-909 is the first SMARCA2 selective inhibitor to enter the clinic. Dosing the first patient marks an important milestone for the program and our collaboration with Lilly,” said Adrian Gottschalk, President and Chief Executive Officer of Foghorn. “FHD-909 has high selectivity over closely related SMARCA4, offering a promising synthetic lethality strategy for prevalent SMARCA4 mutations and their sensitivity to SMARCA2 inhibition in NSCLC and other solid tumors. We look forward to continued advancement of FHD-909 in partnership with Lilly.”

A Phase 1 open-label, multicenter trial will assess the safety, tolerability and initial efficacy of FHD-909 in patients with locally advanced or metastatic solid tumors harboring a SMARCA4 alteration.

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