Significant Positive Results with Jaguar Health’s Crofelemer for Cancer Therapy-Related Diarrhea (CTD) in Breast Cancer Patients Presented at San Antonio Breast Cancer Symposium (SABCS)

Adult patients with breast cancer are a prespecified subgroup of the recently conducted phase 3 OnTarget trial evaluating crofelemer for prophylaxis of CTD

The majority of patients in the OnTarget placebo group on abemaciclib and pertuzumab-based therapies required dose reduction or elimination

Excerpt from the Press Release:

SAN FRANCISCO, CA / ACCESSWIRE / December 12, 2024 / Jaguar Health, Inc. (NASDAQ:JAGX) (“Jaguar”) family company Napo Pharmaceuticals (“Napo”) today provided an overview of the data from the poster presentation conducted yesterday, December 11, 2024, at the San Antonio Breast Cancer Symposium (SABCS) about the recently completed analysis of the prespecified subgroup of adult patients with breast cancer from the Phase 3 OnTarget trial, which indicates that crofelemer achieved statistically significant results in this subgroup. Patients with breast cancer accounted for 183 of the 287 participants in this unprecedented prophylactic clinical trial recently conducted by Napo for diarrhea in adults with solid tumors receiving targeted therapy with or without standard chemotherapy.

“In this responder analysis of patients with breast cancer on targeted therapies, crofelemer CTD prophylaxis resulted in a greater proportion of monthly responders of diarrhea improvement compared to placebo,” said Lisa Conte, Jaguar’s president and CEO. “Overall, crofelemer was significantly more effective than placebo in providing sustained response in breast cancer patients, potentially helping them stay on their cancer therapies. This research underscores the potential of crofelemer for prophylaxis of CTD.”

“Diarrhea is a common side effect of targeted therapies and can lead to dose changes, treatment delays, or stopping treatment altogether, all of which can impact patient outcomes,” said Pablo C. Okhuysen, MD, FACP, FIDSA, the National Principal Investigator of the OnTarget trial. “The OnTarget study specifically analyzed breast cancer patients receiving crofelemer or a placebo for 12 weeks. Patients reported their diarrhea symptoms, and those with fewer than nine loose stools per week were considered ‘responders.’ Breast cancer patients receiving crofelemer had significantly better control of diarrhea than those on placebo. Nearly half (47.1%) of crofelemer group patients were responders through 12 weeks, compared to 33.7% of those on placebo.”

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