Pre-Clinical Testing

Alcresta Therapeutics Announces Preclinical Data Showing ALC-078 Cartridge Use in SBS Model Was Associated with Improved Fat and Nutrient Absorption

05/06/2022

Preclinical data published in Journal of Clinical Nutrition highlight potential applications of ALC-078 cartridge in short bowel syndrome nutrition management Excerpt from the Press Release: NEWTON, Mass. , April 27, 2022 /PRNewswire/ — Alcresta Therapeutics, Inc., a leading commercial-stage company focused on developing and commercializing novel enzyme-based products, today announced publication of preclinical data from the company’s development…

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Virpax Successfully Completes Initial Preclinical Studies for VRP324

05/05/2022

-Nasal CBD Candidate to Manage Seizures Associated with Epilepsy in Children and Adults- Excerpt from the Press Release: Virpax® Pharmaceuticals, Inc. (“Virpax” or the “Company”) (NASDAQ: VRPX), a company specializing in developing non-addictive product candidates for pain management, CNS disorders and anti-viral indications, reported preclinical pharmacokinetics (PK) results for VRP324 (MET-CBD), a nose-to-brain delivery platform for CBD…

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CureVac and GSK’s Bivalent Second-Generation mRNA Vaccine Candidate Shown to be Highly Effective Against SARS-CoV-2 Variants in Preclinical Study

04/26/2022

– Vaccine candidate combining Beta- and Delta-specific mRNAs shows strong protection and immune responses during preclinical challenge study – Demonstrated neutralizing capacity against the Omicron variant in vaccinated animals – Technology adaptation for bivalent approach for COVID-19 vaccines potentially allows for broader protection against emerging variants Excerpt from the Press Release: TÜBINGEN, GERMANY and BOSTON,…

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Sciwind Biosciences Announces Initiation of Dosing in Phase 1 Clinical Trial Evaluating XW004, an oral tablet formulation of its Proprietary GLP-1 Analogue (Ecnoglutide)

04/25/2022

Excerpt from the Press Release: HANGZHOU, China and SAN FRANCISCO, April 13, 2022 /PRNewswire/ — Sciwind Biosciences Co., Ltd., a clinical-stage biopharmaceutical company focused on discovering and developing innovative therapies to treat metabolic disease, today announced the initiation of subject dosing in its Phase 1 clinical trial of XW004. XW004 is an oral tablet formulation of Ecnoglutide, a novel…

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Foghorn Therapeutics Presents New Preclinical Data on Novel BRG1/BRM Inhibitor FHD-286 at the 2022 AACR Annual Meeting

04/22/2022

Excerpt from the Press Release: CAMBRIDGE, Mass., April 13, 2022 (GLOBE NEWSWIRE) — Foghorn® Therapeutics Inc. (Nasdaq: FHTX), a company pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, today announced preclinical data supporting the clinical development and mechanistic understanding of BAF inhibition through the…

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Treatment Developed by CHOP Researchers Prevents Hypoglycemia in Children with Hyperinsulinism

04/21/2022

In a phase 2a study, CHOP researchers showed exendin-(9-39) leads to blood sugar control in children with HI, which could improve care for a rare condition with few treatments Excerpt from the Press Release: PHILADELPHIA, April 13, 2022 /PRNewswire/ — Researchers at Children’s Hospital of Philadelphia (CHOP) have shown that a targeted treatment they developed is effective at controlling…

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Atreca Announces Expansion of Preclinical Pipeline

04/12/2022

Atreca Announces Licensing Agreement with Zymeworks Atreca Declares EphA2-Targeting ADC (ATRC-301) as Clinical Candidate Virtual R&D Day scheduled for today at 4:15 p.m. EDT Excerpt from the Press Release: SAN CARLOS, Calif., April 05, 2022 (GLOBE NEWSWIRE) — Atreca, Inc. (Atreca) (NASDAQ: BCEL), a clinical-stage biotechnology company focused on developing novel therapeutics generated through a…

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Regulus Therapeutics Announces Initiation of Preclinical Studies in Amyotrophic Lateral Sclerosis under a Collaboration Agreement with Harvard’s Brigham and Women’s Hospital

04/04/2022

– Preliminary data are expected in the second half of 2022 Excerpt from the Press Release: SAN DIEGO, March 24, 2022 /PRNewswire/ — Regulus Therapeutics Inc. (Nasdaq: RGLS), a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the “Company” or “Regulus”), today announced the initiation of studies evaluating a library of oligonucleotides designed to…

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Seres Therapeutics Presents Preclinical Research on Investigational Microbiome Therapeutic SER-155 at the 2022 European Bone Marrow Transplantation Annual Meeting

03/28/2022

– Preclinical data demonstrate SER-155 reduces infection and Graft-versus-Host Disease – Excerpt from the Press Release: CAMBRIDGE, Mass.–(BUSINESS WIRE)–Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, will present preclinical findings tomorrow at the European Bone Marrow Transplantation (EBMT) Annual Meeting that suggest SER-155 works by targeting the host immune response, potentially allowing patients undergoing…

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Cortexyme Announces Preclinical Data Highlighting Potential Therapeutic Benefits of Atuzaginstat for the Treatment of High-Risk Oral Potentially Malignant Disorders

03/15/2022

First-in-class lysine gingipain inhibitor, atuzaginstat, has the potential to reduce the malignant progression of oral potentially malignant disorders (OPMD) In vitro study results demonstrate that PD-L1 is induced by P. gingivalis and can be blocked by atuzaginstat Atuzaginstat ready to begin a Phase 2 trial for expansion into high-risk OPMD indication; IND submission expected in…

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