SARS-CoV-2 Infection Prevented and Treated in Human Lung Tissue Model
Excerpt from the Article:
Given the steady numbers of new COVID-19 cases, the appearance of new variants, and the considerable time that vaccinations will take to reach target levels needed for herd immunity, the development of treatments and useful therapeutics remains a top priority. In particular, treatments and preventive approaches that can be widely and rapidly implemented are urgently needed to curb the risk for COVID-19 related hospitalization and death in multiple settings including nursing homes and long-term care facilities.
Now, scientists at UNC have found that the orally administered experimental drug EIDD-2801 (now known as molnupiravir or MK-4482) halts SARS-CoV-2 replication and prevents infection of human cells in a new in vivo lab model containing human lung tissue. Separate Phase II and III clinical trials are ongoing to evaluate molnupiravir safety in humans and its effect on viral shedding in COVID-19 patients, and the first results could be released as early as March.
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