Baylor College of Medicine Presents eFFECTOR Therapeutics-Backed Preclinical Data Supporting Development of Zotatifin in Triple-Negative Breast Cancer at 2021 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

• Demonstrated statistically significant anti-tumor activity and inhibited proliferative and stem-cell signaling pathways

• Induced beneficial changes in the tumor microenvironment by increasing production of proteins involved in interferon- α and interferon- γ pathways

• Demonstrated statistically significant increases in survival when combined with carboplatin and everolimus (mTOR inhibitor)

Excerpt from the Press Release:

SAN DIEGO, Oct. 07, 2021 (GLOBE NEWSWIRE) — eFFECTOR Therapeutics (NASDAQ: EFTR), a leader in the development of selective translation regulator inhibitors (STRIs) for the treatment of cancer, in collaboration with investigators at Baylor College of Medicine, today announced the presentation of new positive data for zotatifin in animal models of triple-negative breast cancer (TNBC) at the 2021 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Zotatifin is a potent and sequence-selective inhibitor of eukaryotic translation initiation factor 4A (eIF4A) mediated translation.

The study authors found that blocking eIF4A in p53-null models of mouse mammary tumorigenesis with zotatifin results in tumor control via both tumor-intrinsic mechanisms as well as activation of host immune response. This activity is further potentiated with the addition of chemotherapy. The presentation entitled, “The RNA helicase EIF4A is a therapeutic vulnerability in triple-negative breast cancer,” was presented by Na Zhao, Ph.D., postdoctoral associate in the Jeffrey Rosen Lab, Department of Molecular and Cellular Biology, Baylor College of Medicine, in an oral session.

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