2seventy bio Announces Plans to Initiate KarMMa-9 Study of Abecma (idecabtagene vicleucel) in Newly Diagnosed Multiple Myeloma Patients
This study will evaluate Abecma in patients with suboptimal response to transplant
Data from KarMMa-3 and KarMMa-2 studies of Abecma will be presented at future medical meeting
Excerpt from the Press Release:
CAMBRIDGE, Mass.–(BUSINESS WIRE)–2seventy bio, Inc. (Nasdaq: TSVT) today announced plans to initiate the KarMMa-9 study to evaluate Abecma (idecabtagene vicleucel) in newly diagnosed multiple myeloma patients who have suboptimal response to transplant. The company, in partnership with Bristol Myers Squibb, plans to provide additional information about the design and timing of the study at the earliest upcoming opportunity.
“Our focus at 2seventy is giving as much time as possible to patients who are battling cancer. We are moving rapidly to expand our clinical study program to determine utility of Abecma in newly diagnosed multiple myeloma patients with suboptimal response to transplant,” said Steve Bernstein, chief medical officer, 2seventy bio. “This population currently makes up more than half of multiple myeloma patients receiving transplant. Given the efficacy data from our collective KarMMa studies and well-established and predictable safety profile seen in studies replicated in the real-world, we believe there is tremendous potential for Abecma to help some of these patients earlier in their treatment path.”
“Given the performance over other treatment options, autologous stem cell transplant will most likely continue to be the standard of care in patients newly diagnosed with multiple myeloma who are eligible,” said Nikhil Munshi, M.D., Director of Basic and Correlative Science at the Jerome Lipper Multiple Myeloma Center, Kraft Family Chair, and senior physician at Dana-Farber Cancer Institute, as well as a professor of medicine at Harvard Medical School. “However, a high unmet clinical need remains, specifically in patients who have a suboptimal response to transplant. The investigation of a well-established CAR T cell therapy, such as Abecma, in the newly diagnosed multiple myeloma treatment paradigm will be an important next step.”
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