Biosplice Therapeutics Announced New Clinical Data for Cirtuvivint (SM08502) at the European Society for Clinical Oncology Meeting

Results showed evidence of clinical activity for cirtuvivint in advanced cancer patients

Excerpt from the Press Release:

SAN DIEGO, Sept. 29, 2022 (GLOBE NEWSWIRE) — Biosplice Therapeutics, Inc. (“Biosplice”), a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major diseases, announced today the presentation of new clinical data for cirtuvivint (SM08502), its first-in-class small-molecule CLK/DYRK inhibitor. The oral presentation was delivered in Paris, France at the 2022 European Society for Clinical Oncology (ESMO) meeting. With evidence of clinical benefit, cirtuvivint is currently progressing through two Phase 1 trials as a drug candidate for the treatment of advanced solid tumors. In addition, Biosplice is developing next-generation, highly-selective drug candidates within its CLK/DYRK target class for a broader array of cancers, including liquid tumors.

The oral presentation, entitled “Preliminary evidence of clinical activity from Phase 1 and 1b trials of the CLK/DYRK inhibitor cirtuvivint (CIRT) in subjects with advanced solid tumors,” was delivered by Dr. Aaron Scott, MD from the University of Arizona Cancer Center. The first-in-human Phase 1 study evaluated the pharmacokinetics, pharmacodynamics, safety, and efficacy of cirtuvivint in subjects with advanced solid tumors while the Phase 1b study combined cirtuvivint with standard-of-care agents in castrate-resistance prostate cancer, colorectal cancer, and non-small cell lung cancer. Preliminary results from the cirtuvivint dose escalation in these two studies provided early evidence of clinical activity with a manageable safety profile in a heavily pre-treated advanced cancer patient population. In addition, the preliminary data from the combination trial suggested that in castrate-resistance prostate cancer, hormonal therapy resistance may be overcome when cirtuvivint is combined with abiraterone acetate.

“We are enthusiastic about the promising early clinical activity observed with our first in class CLK/DYRK inhibitor cirtuvivint in this difficult-to-treat Phase 1 cancer patient population,” said Darrin Beaupre, M.D., PhD, Chief Medical Officer in Oncology at Biosplice Therapeutics. “Alternative splicing has been reported to be a driver for many of the hallmarks of cancer, including growth, survival, and drug resistance; the spliceosome itself has been identified as therapeutic vulnerability in a number of solid and liquid tumors. We are pleased to be making progress in exploiting this vulnerability with cirtuvivint”.

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