Eureka Therapeutics Announces New England Journal of Medicine Publication of Clinical Study Demonstrating GPRC5D as an Active Target for the Treatment of Multiple Myeloma
Excerpt from the Press Release:
EMERYVILLE, Calif.–(BUSINESS WIRE)–Eureka Therapeutics, Inc., a clinical-stage biotechnology company developing novel T cell therapies to treat cancer, today announced the publication of a study in the New England Journal of Medicine entitled “GPRC5D-Targeted CAR T Cells for Myeloma.” The study was led by Dr. Eric Smith of the Dana-Farber Cancer Institute, Dr. Renier Brentjens of the Roswell Park Comprehensive Cancer Center, and Dr. Sham Mailankody of the Memorial Sloan Kettering Cancer Center (MSK).
The GPRC5D binder used in the study was developed by Eureka using its proprietary E-ALPHA® platform in collaboration with MSK. Eureka and MSK licensed the binder to Juno Therapeutics/Bristol Myers Squib in 2016 for CAR use, and to Sanofi in 2021 for non-CAR use.
While B cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapies have generated responses in patients with multiple myeloma, relapses associated with low-to-negative expression of BCMA are common. Preclinical studies have shown the efficacy of G protein-coupled receptor, class C, group 5, member D (GPRC5D)-targeted CAR T-cell therapy in multiple myeloma, including in BCMA antigen escape models (Smith EL et al. Science Trans Med 2019).
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