Merus Presents First in Human Data on MCLA-129 at the 34th EORTC/NCI/AACR (ENA) Symposium on Molecular Targets and Cancer Therapeutics
– MCLA-129 observed to be well tolerated with a favorable safety profile
– Antitumor activity was observed among heavily pretreated patients, across multiple tumor types and dose levels
– Initial recommended phase 2 dose 1500 mg every two weeks; expansion cohorts enrolling
– Investor call to discuss a MCLA-129 program update on October 26 at 13:30 CET/7:30am ET
Excerpt from the Press Release:
UTRECHT, The Netherlands and CAMBRIDGE, Mass., Oct. 26, 2022 (GLOBE NEWSWIRE) — Merus N.V. (Nasdaq: MRUS) (“Merus”, “the Company”, “we”, or “our”), a clinical-stage oncology company developing innovative, full-length multispecific antibodies (Biclonics® and Triclonics®), today announced the publication of interim data as of an August 15, 2022 data cutoff, from the ongoing phase 1/2 trial of the bispecific antibody MCLA-129, on the 34th EORTC/NCI/AACR Symposium on Molecular Targets and Cancer Therapeutics (ENA Symposium) website. MCLA-129 is a fully human ADCC enhanced IgG1 Biclonics® bispecific antibody that binds to EGFR and c-MET and is being investigated in patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors. This phase 1/2 study has completed the dose escalation phase and is on-going in the dose expansion phase.
The poster is now available on the Merus website and will be presented at the 34th ENA Symposium in Barcelona, Spain on Friday, October 28, 2022, 10:00-15:00 CET.
“These initial data provide encouraging clinical evidence that MCLA-129 has the potential to be meaningful in patients with solid tumors including NSCLC,” said Dr. Andrew Joe, Chief Medical Officer at Merus. “We look forward to continuing the dose expansion portion of this trial to further evaluate the efficacy and safety of MCLA-129 both as monotherapy and in combination with a third generation EGFR TKI.”
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