Jasper Therapeutics Announces Positive Follow-up Clinical Data from Investigator-Sponsored Study of Briquilimab Conditioning in Fanconi Anemia Patients at the 2023 Transplantation & Cellular Therapy Meetings of the ASTCT and CIBMTR

• Both Fanconi Anemia patients treated with briquilimab successfully engrafted with neutrophil engraftment within 11 days
• 100% total donor chimerism was achieved through six months for the first patient and through three months for the second patient
• Both patients are doing well post-transplant with briquilimab-based conditioning

Excerpt from the Press Release:

REDWOOD CITY, Calif., Feb. 17, 2023 (GLOBE NEWSWIRE) — Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a biotechnology company focused on developing novel antibody therapies targeting c-Kit (CD117) to address diseases such as chronic spontaneous urticaria and lower to intermediate risk myelodysplastic syndromes (MDS) as well as novel stem cell transplant conditioning regimes, today announced that new follow-up data from Jasper’s investigator-sponsored study of briquilimab (formerly known as JSP191) as a conditioning agent in the treatment of Fanconi Anemia (FA) were presented in a poster presentation today at the 2023 Tandem Meetings: Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR taking place in Orlando, Florida.

The study is a Phase 1/2 clinical trial (NCT04784052) utilizing briquilimab to treat FA patients in bone marrow failure requiring allogeneic transplant with non-sibling donors. The objective of the study is to develop cell therapy, which enables blood and immune reconstitution in FA patients with decreased toxicity, by using briquilimab as a part of conditioning which eliminates the need for busulfan chemotherapy or total body irradiation.

In the follow-up data series presented, 100% total donor chimerism was achieved through six months for the first patient and at three months for the second patient. Neutrophil engraftment was reached on day 11 for both patients and platelet engraftment was achieved on days 14 and 9 for the first and second patient, respectively. Briquilimab was cleared by day 9 after dosing in both patients and no treatment-related adverse events or toxicities were observed.

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