Takeda Announces Positive Topline Results from Phase 2b Study Evaluating TAK-279, a Highly Selective Oral TYK2 Inhibitor, for the Treatment of Active Psoriatic Arthritis
− Topline Results for TAK-279 Show that a Significantly Greater Proportion of Psoriatic Arthritis Patients Achieved at Least an ACR20 Response Compared to Placebo at Week 121
− Based on the Positive Results, Takeda Intends to Initiate a Phase 3 Study of TAK-279 in Psoriatic Arthritis
− Full Clinical Results Will be Presented at an Upcoming Medical Meeting
Excerpt from the Press Release:
OSAKA, Japan & CAMBRIDGE, Mass.–(BUSINESS WIRE)–Takeda (TSE:4502/NYSE:TAK) today announced positive topline results from its randomized, double-blind, placebo-controlled, multiple-dose Phase 2b trial evaluating TAK-279, an investigational oral allosteric tyrosine kinase 2 (TYK2) inhibitor with next generation selectivity, in people with active psoriatic arthritis. The study met its primary endpoint with a greater proportion of patients treated once-daily with TAK-279 achieving at least a 20 percent improvement in signs and symptoms of disease (American College of Rheumatology 20 response) at week 12 compared to placebo, supporting its potential as a highly selective oral option for patients with psoriatic arthritis.1 The safety and tolerability profile of TAK-279 in the Phase 2b trial was consistent with previous TAK-279 clinical trials.1 Analysis of the results are ongoing, and Takeda plans to present clinical results at an upcoming medical meeting.
“Psoriatic arthritis can impose a profound burden on patients and there is an unmet need for therapeutic options that combine efficacy, safety, tolerability and convenience. These Phase 2b results highlight the potential of TAK-279, a highly selective, oral TYK2 inhibitor, to improve clinical outcomes for people living with psoriatic arthritis,” said Andy Plump, President R&D, Takeda. “Our hypothesis is that high selectivity, as seen with TAK-279, can enable high levels of TYK2 inhibition, while potentially avoiding toxicities associated with JAK inhibition. We look forward to sharing the results soon and exploring the potential of TAK-279 in further clinical studies.”
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